The Human Brain Supercomputer is a top-secret experiment created by Neo Zeed, and is tasked to pilot the organization's air carrier which is housed at a private military base. It was able to detect Joe Musashi after he stowed away onto the air carrier. Unable to move itself, the Supercomputer attacks Musashi with its laser defense system but is destroyed.
The Human Brain Supercomputer was restored when Neo Zeed resurfaced. Now stationed in a high-tech facility to defend Zeed Laboratory and its hideous bioexperiments, it was given an armored pod to move in and was outfitted with various missile and beam weapons, as well as a teleportation system and a reality-distortion field to confuse Musashi's attacks. Despite the advances in its abilities, it was again destroyed by Musashi.